STAT 200 – Introductory Statistics
December 3, 2025
After today’s lecture, you should:
Neurologists want to study the effect of Vitamin C on nerve pain. The goal of the study is to see if taking an intravenous dose of Vitamin C will reduce the amount of nerve pain reported by patients.
To achieve this goal, the researchers advertise at their local university for volunteers with nerve pain. Each member of the study is put into one of two groups: control (no Vitamin C) and treatment (\(5000mg\) Vitamin C daily).
At the start of the study, everyone is given a pain-scale analysis (wherein the patient identifies the level of nerve pain from a scale of 0 to 10). At 90 days, everyone repeats the analysis.
Use the previous description and identify the following:
Variables are at the heart of statistics. They are what we measure on our subjects, and they are what we analyze.
Different types of variables contain different levels of information.
While there are several ways to categorize variables based on their characteristics, here are three different classification systems to consider:
All three schemes are useful in helping us better understand what can and cannot be done with certain variables, and what they can describe.
Qualitative data, also known as categorical data, consist of labels or descriptions of traits.
Examples:
Quantitative data, also known as numeric data, consist of counts or measurements.
Examples:
Be careful! Just because a variable is a number does not mean that it is necessarily quantitative.
For instance, your Knox ID is not a quantitative data; as an identifier, it is a label for you, thus a qualitative variable.
The way I think about it is if your variable has a unit (inches, pounds, dollars, years, etc.) or if you can take an average of it, it is likely quantitative.
What does it mean to take the average age of everyone in the class? What would it mean to take the average ID number of everyone in the class?
Discrete variables are quantitative variables that can take on only particular values and are usually counts.
Examples:
Continuous variables are quantitative variables that can take on any value in a given interval and are usually measurements.
Examples:
The level of measurement of a variable describes the amount of information that variable contains.
Mnemonic Device: {*NOIR**} (“black” in French)
The level of measurement of a variable describes the amount of information that variable contains. The four levels are:
| Nominal | Ordinal | Interval | Ratio |
|---|---|---|---|
| Qualitative | Qualitative | Quantitative | Quantitative |
| Order is meaningful | Order is meaningful | Order is meaningful | |
| Differences between values are meaningful | Differences between values are meaningful | ||
| Zero indicates absence |
Identify each of the following as quantitative or qualitative (numeric or categorical):
Identify each of the following as continuous or discrete:
Identify the level of each of the following variables (nominal, ordinal, interval, or ratio):
These are the general steps to conduct a legitimate scientific study:
Determine the design of the study.
Collect the data.
Organize the data.
Analyze the data to answer the question.
There are two basic types of scientific experiments. They are:
An observational study takes the subjects as they are. In an experiment, generally, the researchers assign the subjects to groups randomly.
There is only one purpose/goal of the sample: It must be representative of the population.
A representative sample has the same relevant characteristics as the population and does not favor one group from the population over another.
Note: A sample can be representative for one characteristic of the population (parameter) but not for another. In fact, it can be representative in every single parameter, but not for the relationships between them.
How does one know if a sample is representative of the population?
Broadly speaking, a statistical study is either experimental or observational. There are a few main types of observational studies:
In a cross-sectional study, data are collected at a single point in time.
In a time-series study, data are gathered by following a single person over a period of time.
In a longitudinal study, data are gathered by following a particular group over a period of time.
In a cross-sectional-time-series study, data are gathered by following a larger group over a period of time.
Here is some terminology related to scientific experiments. Some of these we have already used, others not.
The subjects (participants) are people or things being studied in an experiment.
A treatment is some condition that is applied to a group of subjects in an experiment.
Here is some terminology related to scientific experiments. Some of these we have already used, others not.
The response variable is the variable in an experiment that responds to the treatment. This type of variable is also termed the dependent variable.
The explanatory variable(s) is the variable (or variables) in an experiment that causes the change in the response variable. This type of variable is also termed the independent variable.
Here is some terminology related to scientific experiments. Some of these we have already used, others not.
A control group is a group of subjects to which no treatment is applied in an experiment.
Here is some terminology related to scientific experiments. Some of these we have already used, others not.
A treatment group is a group of subjects to which researchers apply a treatment in an experiment.
The confounding variables are unmeasured factors that cause an effect on the subjects of an experiment.
To properly perform a scientific experiment, one should:
completely randomize the control and treatment groups.
control for outside effects on the response variable.
analyze a sufficiently large sample.
replicate the experiment a significant number of times to see meaningful patterns.
For more information on case-control studies: Please read the two pages that is “Epidemiology in Practice: Case-Control Studies” (Lewallen and Courtright, 1998) located at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1706071/.
There are reasons behind these fundamental principles. They delve into the goal of ensuring the sample is representative of the population.
How can we ensure experiments are properly performed?
In a single-blind experiment, subjects do not know if they are in the control group or the treatment group, but the people interacting with the subjects in the experiment know in which group each subject has been placed.
In a double-blind experiment, neither the subjects nor the people interacting with the subjects know to which group each subject belongs.
An Institutional Review Board is a group of people who review the design of a study to make sure that it is appropriate and that no unnecessary harm will come to the subjects.
The Institutional Review Board (IRB) at Knox College is responsible for overseeing all research at Knox College that involves the use of human subjects. The ultimate goal of the IRB is to safeguard the well-being of individuals who participate in research conducted by Knox College and/or its faculty, staff, and students and to ensure that research occurring at Knox College meets accepted ethical standards. The Knox IRB also reviews projects conducted by outside researchers who wish to collect data from members of the Knox College community.
This information — and more — about the Knox College IRB can be found at https://www.knox.edu/offices/academic-affairs/institutional-review-board
Informed consent involves completely disclosing to participants the goals and procedures involved in a study and obtaining their agreement to participate.